Table 1 Optimization conditions of the synthesis of N-cyclohexyl-2-(4-methyl-1-oxoisoquinolin-2(1H)-yl)-2-phenylacetamide.

Entry	Solvent	Base	Amount of catalyst (mol %)	Isolated yield (%)
1	H₂O	K₂CO₃	5	12
2	EtOH	K₂CO₃	5	30
3	DMF	K₂CO₃	5	83
4	DMSO	K₂CO₃	5	75
5	DMF	Et₃N	5	40
6	DMF	Pyridine	5	32
7	DMF	NaOH	5	58
8	DMF	K₂CO₃	0	0
9	DMF	K₂CO₃	3	63
10	DMF	K₂CO₃	8	83
11	DMF	K₂CO₃	mFuVe NPs (100 mg)	0

Reaction conditions: Compound 6 (0.3 mmol), base (0.6 mmol), tetrabutylammonium bromide (0.9 mmol), solvent (1 mL) Pd@mFuVe catalyst, 75 °C.

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