Table 4 Correlation of adjusted dose of vedolizumab with its peak and trough levels.
Weight (kg) | BMI | Adjusted dose (mg/kg) | WK 2 | WK 6 | ||
|---|---|---|---|---|---|---|
Peak level | Trough level | Peak level | Trough level | |||
58.6 | 25.36 | 5.1 | 401.83 | 30.18 | 208.76 | 34.07 |
59.1 | 22.80 | 5.0 | 142.86 | 22 | 195.85 | 7.89 |
55.6 | 23.75 | 5.3 | 169.22 | 43.22 | 158.16 | 3.7 |
33.6 | 15.76 | 8.9 | 321.92 | 42.06 | 221.94 | 40.3 |
45.7 | 23.01 | 6.5 | 564.78 | 46.14 | 267.12 | 59.58 |
48.6 | 18.30 | 6.1 | 665.99 | 18.11 | 248.72 | 19.86 |
56.2 | 24.91 | 5.3 | 200.26 | 23.36 | 167.09 | 25.12 |
45 | 20.49 | 6.6 | 250 | 33.29 | 301.37 | 49.07 |
68.4 | 21.41 | 4.3 | 102.04 | 11.68 | 91.84 | 8.18 |
67.3 | 30.4S | 4.4 | 112.24 | 7.59 | 141.58 | 7.79 |
63 | 16.13 | 4.7 | 181.12 | 39.14 | 213.01 | 13.43 |
84 | 23.18 | 3.5 | 117.35 | 12.58 | 125 | 15.19 |
63.9 | 19.63 | 4.9 | 164.54 | 16.49 | 62.5 | 8.76 |
60.3 | 23.148 | 4.9 | 62.5 | 8.67 | 44.93 | 4.09 |
75 | 21.66 | 4 | 164.54 | 14.6 | 102.04 | 16.36 |
62.6 | 24.52 | 4.7 | 89.29 | 5.84 | 60.16 | 7.59 |
Correlation of level and adjusted dose* | r = 0.71 p = 0.002 | r = 0.70 p = 0.002 | r = 0.69 p = 0.003 | r = 0.49 p = 0.05 | ||
Correlation of level with BMI* | r = − 0.30 p = 0.24 | r = − 0.31 p = 0.24 | r = − 0.32 p = 0.22 | r = − 0.30 p = 0.25 | ||
Correlation of level with weight* | r = − 0.56 p = 0.02 | r = − 0.60 p = 0.01 | r = − 0.57 p = 0.02 | r = − 0.33 p = 0.20 | ||
