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Figure 1

From: An agent-based approach for modelling and simulation of glycoprotein VI receptor diffusion, localisation and dimerisation in platelet lipid rafts

Figure 1

Structure and dimerisation of platelet GPVI receptors. (A) The extracellular ___domain of monomeric GPVI on platelets comprises of two IgG domains and a connection to the transmembrane ___domain (blue). The GPVI protein is stably connected to two chains of the FcR γ-chain, forming ITAM-containing signalling domains. Monomers of GPVI can dimerise with other monomers (dimerisation), a process that is reversible (dissociation). Adapted from Induruwa et al. (2016)27. (B) Crystal structure of human platelet GPVI. Image taken from RCSB PDB (rcsb.org), annotation PDB ID 2GI723. (C) Projected illustration of GPVI as a transmembrane protein with an assigned effective area in two dimensions.

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