Figure 3

Preferential localisation of single receptors in the confined ___domain. (A) Snapshots of 11 simulations of 47 receptors (red dots) moving on the simulated membrane with confined ___domain (yellow circle). Note the sub-micrometer size of the simulation box of 0.3 × 0.3 μm, and the initial random distribution of GPVI receptors. Simulations were run for ≥ 200,000 steps, with an average of the last 50,000 steps shown. The diffusivity ratio between outside and inside confined domains, Dout:Din, was changed from 1 (20) to 1024 (210). The snapshots shown are for Dout:Din = 1, 4, 16, 64, 256 and 1024. (B) Effect of an altered ratio Dout:Din on number of receptors inside the confined ___domain. Each simulation was repeated three times, means ± SD.