Table 2 Univariate and multivariate analysis of LVI, PNI and other related factors.
From: Prognostic impact of lymphovascular and perineural invasion in squamous cell carcinoma of the tongue
| Â | Overall survival | |||
|---|---|---|---|---|
Univariate analysis | Multivariate analysis | |||
HR (95% CI) | p-value | HR (95% CI) | p-value | |
Gender | ||||
 Female |  | 0.66 |  |  |
 Male | 1.168 (0.585–2.329) |  | ||
Age (years) | ||||
  < 60 |  | 0.947 |  |  |
  ≥ 60 | 1.024 (0.513–2.043) |  | ||
Smoking | ||||
 No |  | 0.293 |  |  |
 Yes | 0.622 (0.257–1.508) |  | ||
Alcohol | ||||
 No |  | 0.702 |  |  |
 Yes | 0.849 (0.369–1.957) |  | ||
Pathologic T stage | ||||
 T1-2 |  | 0.144 |  |  |
 T3-4 | 1.74 (0.827–3.661) |  | ||
Pathologic N stage | ||||
 0 |  |  < 0.001 |  | 0.452 |
 1 | 3.117 (1.32–7.364) | 1.103 (0.255–4.773) | ||
 2 | 6.108 (2.728–13.677) | 1.954 (0.459–8.319) | ||
Tumor stage | ||||
 I-II |  | 0.001 |  | 0.821 |
 III-IV | 3.303 (1.622–6.725) | 1.165 (0.311–4.356) | ||
Histological grade | ||||
 Poorly |  | 0.006 |  | 0.058 |
 Moderately | 5.116 (1.381–18.954) | 2.281 (0.568–9.16) | ||
 Well | 3.136 (1.435–6.856) | 0.861 (0.191–3.879) | ||
Postoperative radiotherapy | ||||
 No |  | 0.037 |  | 0.193 |
 Yes | 2.263 (1.051–4.872) | 1.739 (0.756–3.999) | ||
LVI | ||||
 Negative |  |  < 0.001 |  | 0.001 |
 Positive | 7.56 (3.645–15.684) | 4.537 (1.871–11.001) | ||
PNI | ||||
 Negative |  |  < 0.001 |  | 0.004 |
 Positive | 3.497 (1.731–7.063) | 3.309 (1.466–7.472) | ||
