Figure 1

(a) Kaplan–Meier survival plot for 24-h intervention groups. Time to death in days for the control group and 24 h post-exposure ceftazidime treated groups (IP administration). Treatments were administered twice daily (BID) or four times daily (QID). BID low dose = 300 mg/kg/treatment, totaling 600 mg/kg/day. BID high dose = 600 mg/kg/treatment, totaling 1200 mg/kg/day. QID low dose = 150 mg/kg/treatment, totaling 600 mg/kg/day. QID high dose = 300 mg/kg/treatment, totaling 1200 mg/kg/day. Survival rates in Groups 4, 7, and 8 at the end of treatment were significantly greater than the control group (p = 0.0002, 0.0383, and 0.002, respectively). Survival rates in Groups 4 and 8 at Study Day 45 (30 days post-cessation of treatment) were significantly greater than the control group (p = 0.0035). Survival rates were not significantly different between the control group and any treated group at Study Day 75. (b) Kaplan–Meier Survival Plot for 48-Hour Intervention Groups. Time to death in days for the control group and 48 h post-exposure ceftazidime treated groups (IP administration). Treatments were administered twice daily (BID) or four times daily (QID). BID low dose = 300 mg/kg/treatment, totaling 600 mg/kg/day. BID high dose = 600 mg/kg/treatment, totaling 1200 mg/kg/day. QID low dose = 150 mg/kg/treatment, totaling 600 mg/kg/day. QID high dose = 300 mg/kg/treatment, totaling 1200 mg/kg/day. At this initiation time point, a single animal survived in the high dose QID group. Time to death in the 48 h post-exposure treatment groups (52.5–58.1 h) was similar to the control group (53.2 h).