Table 2 P-values from Boschloo’s tests comparing survival proportions between each pair of timepoints within each group.

From: Efficacy of ceftazidime in a murine model following a lethal aerosol exposure to Burkholderia pseudomallei

Group

Group description

P-value#

End of treatment vs day 45

End of treatment vs end of study

Day 45 vs end of study

2

Saline control

1.0000

1.0000

1.0000

3

24 h low BID

1.0000

1.0000

1.0000

4

24 h high BID

0.3296

0.0001*

0.0017*

5

48 h low BID

1.0000

1.0000

1.0000

6

48 h high BID

1.0000

1.0000

1.0000

7

24 h low QID

1.0000

0.5920

0.8011

8

24 h high QID

0.5264

0.0683

0.5264

9

48 h low QID

1.0000

1.0000

1.0000

10

48 h high QID

1.0000

1.0000

1.0000

  1. Statistical comparison of survival proportions within the control and each treated group at specific stages post-treatment including the end of treatment, 30 days post-cessation of treatment (Day 45), and the end of study. The survival rate of the 24 h high dose BID treated group was significantly less at the end of study compared to the end of treatment and Day 45, illustrating twice daily treatment likely does not meet the required threshold of %fT > *4MIC to adequately clear infection as significant changes in survival rate were not observed in the low dose and high dose QID treated groups at the same time points.
  2. #P-value is for two-sided Boschloo’s test comparing survival rates between each pair of timepoints within each group. Overall error rate of the three tests is controlled at 5% using the Bonferroni-Holm multiple comparison procedure.
  3. *Survival rates are significantly different between the timepoints.