Table 3 Kaplan–Meier median times to death with 95% confidence intervals and P-values from log rank tests comparing times to death between each of the treated groups and the vehicle group.

From: Efficacy of ceftazidime in a murine model following a lethal aerosol exposure to Burkholderia pseudomallei

Group

Group description

No. died/no. in group

Kaplan–Meier median time to death in hours (95% confidence interval)

P-value#

2

Saline control

10/10

53.19 (51.15, 57.55)

 

3

24 h low BID

10/10

140.17 (77.55, 142.07)

 < 0.0001*

4

24 h high BID

10/10

1400.62 (141.02, 1441.08)

 < 0.0001*

5

48 h low BID

12/12

57.09 (53.68, 60.62)

0.1495

6

48 h high BID

12/12

54.23 (52.03, 58.32)

0.6807

7

24 h low QID

8/10

356.31 (100.38, 1659.73)

 < 0.0001*

8

24 h high QID

6/10

1630.67 (81.28, –)

 < 0.0001*

9

48 h low QID

12/12

58.05 (53.6, 67.58)

0.0649

10

48 h high QID

11/12

52.51 (51.43, 58.68)

0.8627

  1. The median time to death of the control group and each treated group and the statistical comparison of the treated groups to the control group. Times to death of the four 48 h post-exposure treatment initiation groups were not significantly different from the control group, indicating that 48 h is too late to therapeutically intervene at the targeted exposure dose. Times to death of the four 24 h post-exposure treatment initiation groups were significantly greater than the control group.
  2. – Upper confidence bound could not be estimated due to large number of surviving animals.
  3. #P-value is for log rank test comparing survival rates between the treated group and the saline control group. Overall error rate of the eight tests is controlled at 5% using the Bonferroni-Holm multiple comparison procedure.
  4. *Time to death of the treated group is significantly greater than that of the control group.
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