Table 3 Cox regression—overall survival.

From: Geriatric nutritional risk index as a prognostic marker for patients with upper tract urothelial carcinoma receiving radical nephroureterectomy

 

Univariate

Multivariable

Hazard ratio

95% CI

p-value

Hazard ratio

95% CI

p-value

Gender

Female

Reference

Reference

 

Reference

Reference

 

Male

1.44

(1.01–2.06)

0.046*

0.75

(0.52–1.09)

0.135

Age

1.03

(1.02–1.05)

 < 0.001**

1.04

(1.02–1.06)

 < 0.001**

GNRI

 ≥ 92

Reference

Reference

 

Reference

Reference

 

 < 92

4.47

(3.10–6.43)

 < 0.001**

3.94

(2.70–5.74)

< 0.001**

Performance status ECOG

0

Reference

Reference

    

1

0.73

(0.44–1.20)

0.209

   

2–4

1.43

(0.82–2.51)

0.209

   

Comorbidity

HTN

1.09

(0.75–1.58)

0.647

   

DM

1.57

(1.05–2.33)

0.027*

0.92

(0.60–1.41)

0.699

COPD/asthema

1.75

(0.72–4.30)

0.220

   

CAD

1.89

(0.92–3.87)

0.082

   

Creatinine > 1.5 mg/dL

1.38

(0.94–2.05)

0.104

   

Smoking status

Never

Reference

Reference

    

Current/former

1.39

(0.95–2.03)

0.094

   

Preoperative renal function

eGFR ≥ 30 ml/min/1.73m2

Reference

Reference

    

eGFR < 30 ml/min/1.73m2

1.42

(0.96–2.10)

0.077

   

History of uremia

Negative

Reference

Reference

    

Positive

1.19

(0.73–1.92)

0.487

   

Surgical margin

Negative

Reference

Reference

 

Reference

Reference

 

Positive

4.62

(3.05–7.02)

< 0.001**

1.78

(1.13–2.82)

0.013*

Pathological T

T1

Reference

Reference

 

Reference

Reference

 

T2

2.33

(1.20–4.52)

0.013*

1.51

(0.77–2.99)

0.232

T3

4.19

(2.64–6.64)

< 0.001**

2.54

(1.53–4.21)

 < 0.001**

T4

18.21

(10.43–31.79)

< 0.001**

6.75

(3.17–14.37)

 < 0.001**

Pathological N

N0

Reference

Reference

 

Reference

Reference

 

N1

3.15

(1.53–6.50)

0.002**

1.23

(0.57–2.63)

0.597

N2–3

6.27

(3.84–10.22)

< 0.001**

1.08

(0.56–2.09)

0.811

Tumor grade

Low

Reference

Reference

 

Reference

Reference

 

High

15.65

(2.18–112.03)

0.006**

7.22

(0.99–52.96)

0.052

Lymphovascular invasion

Negative

Reference

Reference

 

Reference

Reference

 

Positive

4.39

(3.06–6.31)

 < 0.001**

1.81

(1.16–2.81)

0.008**

  1. GNRI geriatric nutritional risk index, ECOG Eastern Cooperative Oncology Group, HTN hypertension, DM diabetes mellitus, COPD chronic obstructive pulmonary disease, CAD coronary artery disease, eGFR estimated Glomerular filtration rate.
  2. Cox proportional hazard regression. *p < 0.05, **p < 0.01.
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