Table 4 Cox regression—disease free survival.

From: Geriatric nutritional risk index as a prognostic marker for patients with upper tract urothelial carcinoma receiving radical nephroureterectomy

 

Univariate

Multivariable

Hazard ratio

95% CI

p-value

Hazard ratio

95% CI

p-value

Gender

Female

Reference

Reference

 

Reference

Reference

 

Male

1.38

(1.08–1.77)

0.011*

1.22

(0.94–1.58)

0.131

Age

1.01

(1.00–1.02)

0.090

   

GNRI

 ≥ 92

Reference

Reference

 

Reference

Reference

 

 < 92

2.19

(1.65–2.90)

< 0.001**

1.90

(1.42–2.54)

 < 0.001**

Performance status ECOG

0

Reference

Reference

    

1

1.15

(0.78–1.68)

0.484

   

2–4

1.35

(0.86–2.11)

0.193

   

Comorbidity

HTN

1.02

(0.79–1.31)

0.898

   

DM

1.36

(1.02–1.82)

0.036*

1.19

(0.88–1.61)

0.271

COPD/asthema

2.12

(1.21–3.71)

0.009**

2.06

(0.98–3.70)

0.113

CAD

1.28

(0.73–2.23)

0.394

   

Creatinine > 1.5 mg/dL

1.28

(0.97–1.69)

0.078

   

Smoking status

Never

Reference

Reference

    

Current/former

1.13

(0.86–1.50)

0.372

   

Preoperative renal function

eGFR ≥ 30 ml/min/1.73m2

Reference

Reference

    

eGFR < 30 ml/min/1.73m2

1.01

(0.76–1.35)

0.942

   

History of uremia

Negative

Reference

Reference

    

Positive

1.08

(0.77–1.53)

0.644

   

Surgical margin

Negative

Reference

Reference

 

Reference

Reference

 

Positive

3.11

(2.22–4.36)

< 0.001**

1.68

(1.13–2.49)

0.010*

Pathological T

T1

Reference

Reference

 

Reference

Reference

 

T2

1.35

(0.89–2.02)

0.154

1.15

(0.75–1.75)

0.520

T3

1.67

(1.25–2.22)

< 0.001**

1.14

(0.82–1.60)

0.436

T4

4.46

(2.94–6.76)

 < 0.001**

1.89

(1.06–3.37)

0.031*

Pathological N

N0

Reference

Reference

 

Reference

Reference

 

N1

1.64

(0.89–3.01)

0.110

0.99

(0.53–1.86)

0.984

N2–3

2.90

(1.90–4.44)

< 0.001**

1.14

(0.68–1.89)

0.626

Tumor grade

Low

Reference

Reference

 

Reference

Reference

 

High

2.37

(1.35–4.14)

0.003**

1.61

(0.90–2.89)

0.110

Lymphovascular invasion

Negative

Reference

Reference

 

Reference

Reference

 

Positive

2.53

(1.94–3.31)

 < 0.001**

1.67

(1.19–2.35)

0.003**

  1. GNRI geriatric nutritional risk index, ECOG Eastern Cooperative Oncology Group, HTN hypertension, DM diabetes mellitus, COPD chronic obstructive pulmonary disease, CAD coronary artery disease, eGFR estimated Glomerular filtration rate.
  2. Cox proportional hazard regression. *p < 0.05, **p < 0.01.
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