Table 5 Cox regression—cancer specific survival.

From: Geriatric nutritional risk index as a prognostic marker for patients with upper tract urothelial carcinoma receiving radical nephroureterectomy

 

Univariate

Multivariable

Hazard ratio

95% CI

p-value

Hazard ratio

95% CI

p-value

Gender

Female

Reference

Reference

 

Reference

Reference

 

Male

1.90

(1.19–3.03)

0.007**

1.93

(1.15–3.23)

0.012*

Age

1.03

(1.00–1.05)

0.022*

1.04

(1.01–1.07)

0.005**

GNRI

 ≥ 92

Reference

Reference

 

Reference

Reference

 

 < 92

6.14

(3.84–9.82)

< 0.001**

5.42

(3.24–9.06)

< 0.001**

Performance status ECOG

0

Reference

Reference

    

1

0.48

(0.27–0.88)

0.588

   

2–4

1.00

(0.50–1.99)

0.996

   

Comorbidity

HTN

1.09

(0.67–1.77)

0.720

   

DM

1.05

(0.59–1.86)

0.867

   

COPD/asthema

1.66

(0.52–5.28)

0.390

   

CAD

1.52

(0.55–4.16)

0.418

   

Creatinine > 1.5 mg/dL

1.47

(0.89–2.41)

0.130

   

Smoking status

Never

Reference

Reference

    

Current/former

1.56

(0.96–2.54)

0.073

   

Preoperative renal function

eGFR ≥ 30 ml/min/1.73m2

Reference

Reference

    

eGFR < 30 ml/min/1.73m2

0.79

(0.44–1.42)

0.435

   

History of uremia

Negative

Reference

Reference

    

Positive

0.55

(0.24–1.27)

0.163

   

Surgical margin

Negative

Reference

Reference

 

Reference

Reference

 

Positive

8.31

(5.15–13.41)

< 0.001**

2.16

(1.26–3.71)

0.005**

Pathological T

T1

Reference

Reference

 

Reference

Reference

 

T2

3.26

(1.03–10.29)

0.044*

2.38

(0.72–7.81)

0.154

T3

10.21

(4.54–22.96)

< 0.001**

6.30

(2.57–15.43)

< 0.001**

T4

56.80

(24.07–134.02)

 < 0.001**

24.79

(8.21–74.87)

< 0.001**

Pathological N

N0

Reference

Reference

 

Reference

Reference

 

N1

6.23

(2.93–13.24)

 < 0.001**

1.50

(0.65–3.47)

0.344

N2–3

11.39

(6.60–19.64)

 < 0.001**

1.23

(0.59–2.55)

0.577

Tumor grade

Low

Reference

Reference

 

Reference

Reference

 

High

8.56

(1.19–61.64)

0.033*

1.84

(0.23–14.52)

0.565

Lymphovascular invasion

Negative

Reference

Reference

 

Reference

Reference

 

Positive

7.07

(4.39–11.38)

 < 0.001**

1.55

(0.86–2.81)

0.148

  1. GNRI geriatric nutritional risk index, ECOG Eastern Cooperative Oncology Group, HTN hypertension, DM diabetes mellitus, COPD chronic obstructive pulmonary disease, CAD coronary artery disease, eGFR estimated Glomerular filtration rate.
  2. Cox proportional hazard regression. *p < 0.05, **p < 0.01.
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