Figure 3 | Scientific Reports

Figure 3

From: Sexual dimorphism during integrative endocrine and immune responses to ionizing radiation in mice

Figure 3

Sex-specific differences in phagocyte function, independent of phagocyte count. 24-week-old male and female C57Bl/6J mice were exposed to GCRsim (0, 15, and 50 cGy) and 3-days post-irradiation blood was collected. Red blood cells were lysed and leukocytes were stained and analyzed by flow cytometry. Phagocytic function was assessed using pH-sensitive E.coli bioparticles to determine the median fluorescence intensity (MFI) of phagocytosis (A, B). Cell count percentages (%) within total leukocytes (CD45+) were determined for monocytes (C), neutrophils (D), and neutrophil-to-lymphocyte ratio (NLR) (E). Parametric statistical analysis was performed on all data. Data represent ± SEM, p* < 0.05, p** < 0.01, n = 10–12 per group.

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