Table 2 Mendelian randomisation analysis of glycaemic traits with colorectal cancer risk.

From: Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation

Phenotype

OR (95% CI)

P value

Fasting glucose levels (mg/dL)

IVW-random effects

1.01 (0.99–1.04)

0.34

MR Egger (P for pleiotropy = 0.12)

0.98 (0.93–1.03)

0.37

Weighted median

1.00 (0.98–1.03)

0.86

MR-PRESSO†

1.00 (0.99–1.02)

0.71

HbA1c (%)

IVW-random effects

1.02 (0.60–1.73)

0.95

MR Egger (P for pleiotropy = 0.23)

0.58 (0.20–1.66)

0.31

Weighted median

0.74 (0.41–1.34)

0.29

MR-PRESSO†

0.89 (0.58–1.37)

0.93

Fasting C-peptide levels (ln ng/mL)

IVW-random effects

1.47 (0.97–2.24)

0.06

MR Egger (P for pleiotropy = 0.56)

1.19 (0.53–2.70)

0.68

Weighted median

1.16 (0.59–2.26)

0.67

MR-PRESSO

1.47 (0.97–2.24)

0.06

  1. †One outlier was detected and corrected in the MR-PRESSO analyses for fasting glucose and HbA1c.
  2. CI confidence interval, HbA1c haemoglobin A1c, IVW inverse-variance weighted, MR Mendelian randomisation, PRESSO Pleiotropy Residual Sum and Outlier, OR odds ratio.
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