Figure 5

Identification of critical kidney genes involved in hyperuricemia. (A) Volcano plot of the differential expressed genes (DEG) between the hyperuricemia mouse and normal mouse kidney tissues. These genes were defined as hyperuricemia kidney DEG. Plot with R (4.2.1) and ggplot2(3.3.6). (B) Heatmap of the hyperuricemia kidney DEG. (C) Intersection analysis between the hyperuricemia KEGG targets (genes in pathways where the hit metabolites are significantly enriched) and hyperuricemia kidney DEG. (D) Normalized expression (log₂(TPM + 0.001)) of critical kidney genes involved in hyperuricemia (means ± SD, all p < 0.05).