Figure 3

Relative expression of four TB signature genes at each site. Using a machine learning analysis, we defined four top genes among the clinical sites (as showed in Supplementary Material). A z-score normalized heatmap was employed to depict overall trends in gene expression among the clinical groups each study site, as indicated. Panels to the right of heatmaps show the average fold-difference between the signature gene expression in the HC group versus TB and TBDM (log-transformed values).