Table 1 Clinical information of the 95 cases.

From: Direct detection and identification of periprosthetic joint infection pathogens by metagenomic next-generation sequencing

Characteristic

MSIS +  (N = 58)

MSIS −  (N = 37)

p

Age* (years)

67.1 ± 12.3

68.2 ± 12.3

0.71

Gender# (male/female)

25/33

17/20

0.62

BMI* (kg/m2)

25.1 ± 5.2

23.4 ± 6.1

0.15

Joint

0.59

 Hip†-initial diagnosis

22 (37.9%)

17 (45.9%)

 

  Joint infection#

16

0

 

  Prosthetic loosening#

2

15

 

  Joint pain#

4

2

 

 Knee†-initial diagnosis

36 (62.1%)

20 (54.1%)

 

  Joint infection#

30

0

 

  Prosthetic loosening#

3

18

 

  Joint pain#

3

2

 

MSIS criteria

 Major criteria†

  2 positive culture

33 (56.9%)

0 (0.0%)

 < 0.001

  Sinus tract connecting with prosthesis

15 (25.9%)

0 (0.0%)

 < 0.001

 Minor criteria

  Serum CRP (mg/L)*

66.8 ± 39.3

6.6 ± 7.3

 < 0.001

  Serum ESR (mm/h)*

70.8 ± 31.3

21.3 ± 16.9

 < 0.001

  Synovial fluid WBC count (cells/μL)*

54,855.7 ± 61,989.5

1560.6 ± 2124.5

 < 0.001

  Synovial fluid PMN percentage (%)*

90.1 ± 12.2

35.6 ± 16.9

 < 0.001

  1. MSIS+ MSIS positive, MSIS− MSIS negative, BMI Body mass index, CRP C-reactive protein, WBC White blood cell, PMN Polymorphonuclear neutrophil.
  2. *The values indicate mean and standard deviation.
  3. #The values indicate the number of cases.
  4. †The values are the number of cases, with the percentage in parentheses.
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