Figure 1

ADAR1 expression in breast cancer. (A) ADAR1 protein expression in malignant versus benign cases; (B) Positive immunohistochemical staining of ADAR1 in normal adjacent tissue, in situ and invasive breast cancer lesions (10X and 40X); (C) Immunoblot analysis of total cell lysates of MDA-MB-231 and MCF7 cells using antibodies against ADAR1and GAPDH; (D) Confocal immunofluorescence images of ADAR1 (green) and nucleus (Dapi) (blue) of breast cancer cells MDA-MB-231 and MCF7. Scale bars, 30 μm; (E) ADAR1 mRNA expression level in non-TNBC in comparison to TNBC tumor tissues using bcGenExMiner v4.8 database; (F) ADAR1 mRNA expression level in with or without lymph nodes involvements in tumor tissues using bcGenExMiner v4.8 database.