Figure 1 | Scientific Reports

Figure 1

From: Heterogeneity of voltage gated sodium current density between neurons decorrelates spiking and suppresses network synchronization in Scn1b null mouse models

Figure 1

Scn1b deletion reduces INa density and density diversity in nucleated patches from subicular pyramidal neurons. (A) Representative INa traces from nucleated patches from subicular pyramidal neurons of Scn1b+/+ and Scn1b−/− mice in acute brain slices. Current elicited by depolarizing steps from − 120 mV to + 30 mV from a holding potential of − 120 mV (traces up to peak are shown for visualization of smaller nested currents). (B) Peak INa density at − 20 mV in nucleated patches as in A n/N = 16/8 Scn1b+/+, 11/8 Scn1b−/−). Diamonds indicate representative traces in A. Asterisks indicate p value (**p < 0.01, Welch’s t-test). (C) Current–voltage relationship from recordings in B. (D) Normalized voltage dependence of steady state activation and inactivation of recordings in B.

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