Figure 3 | Scientific Reports

Figure 3

From: Heterogeneity of voltage gated sodium current density between neurons decorrelates spiking and suppresses network synchronization in Scn1b null mouse models

Figure 3

Scn1b deletion impairs diversity of the spike triggered average current deflection. (A) Scn1b+/+ (left) and Scn1b−/− (right) spike triggered averages for each L6 juvenile neuron recorded in Fig. 1. (B) Average pairwise STA parametric distance from STAs from other cells as shown in A. **p < 0.01, Welch’s t-test. (C) L6 SlickH/Scn1bFl/FL + Veh (left) and L6 SlickH/Scn1bFl/FL + TMX (right) spike triggered averages for each neuron recorded in Fig. 2. (D) Average pairwise STA parametric distance from STAs from other cells shown in C. ***p < 0.001. (E) Scn1b+/+ (left) and Scn1b−/− (right) spike triggered averages for each subicular neuron recorded in Fig. 2. (F) Average pairwise STA parametric distance from STAs from other cells shown in E. **p < 0.01.

Back to article page