Figure 4 | Scientific Reports

Figure 4

From: Heterogeneity of voltage gated sodium current density between neurons decorrelates spiking and suppresses network synchronization in Scn1b null mouse models

Figure 4

Altering INa density decorrelates spiking between conditions without affecting spike train reliability. (A) Spike trains in a WT neuron (top), the same neuron in the presence of 3 nM TTX (middle), and washout (bottom) in response to a time varying stimulus. Raster plot below shows the resulting spike pattern of the stimulus above given over repeated trials during addition and wash off of TTX (n = 6, N = 5). (B) Expanded view of raster plot in A. (C) Average firing rate before, during, and after wash of TTX. (D) Average pairwise correlation between the repeated trials within each condition (i.e. Baseline vs. Baseline). (E) Average pairwise correlation of trains compared between different conditions (i.e. Baseline vs. + TTX). (F) Average phase coherence between the repeated trials within each cell. G. Average phase coherence of trains compared between different conditions. (p < 0.05*, p < 0.01**, p < 0.005***).

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