Figure 6

Classification between epileptogenic and non-epileptogenic nodes in good-outcome patients. For each frequency band, the receiver operating characteristic (ROC) curves estimated from the amplitude envelope correlation (AEC), orthogonalized AEC (oAEC), and phase locking value (PLV)-based nodal strength computed for each node in patients with good surgical outcome (n=22, Engel I) in different epileptogenic states. The highest areas under the ROC curve (AUC) for each epileptogenic state obtained only in specific frequency bands are color-coded: interictal activity with no spikes (“No Spikes”, green-colored), interictal activity with spikes (“Spikes”, blue-colored), pre-ictal activity before the onset of a clinical seizure (“Pre-Ictal”, yellow-colored), ictal activity during a clinical seizure (“Ictal, red-colored), post-ictal activity after the end of a clinical seizure (“Post-Ictal”, orange-colored). The black-colored dash diagonal line represents the performance of FC measures in discriminating the epileptogenicity of nodes that is no better than a random chance. The colored dash diagonal lines represent the maximum Youden index (J) for each epileptogenic state, respectively. The colored-points on the ROC curves represent the cut-off thresholds for each epileptogenic state, respectively. FPR= false positive rate (i.e., 1- specificity); TPR true positive rate (i.e., sensitivity); th threshold.