Figure 3
From: Proton and alpha radiation-induced mutational profiles in human cells
Mutational signatures of SNVs in irradiated human cell lines. (a) Number of point mutations attributed to each of the 10 different extracted SNV mutational signatures, for each sample in our cohort. (b) Exposures of all extracted SNV mutational signatures expressed as a fraction of the total mutation burden in each clone. (c) Decomposition of extracted signatures into PCAWG signature spectra. Values at the top of each bar represent the cosine similarity between the original signature profile and the reconstructed spectrum.
