Figure 6
From: Proton and alpha radiation-induced mutational profiles in human cells
Clustered point mutations associated with irradiation. (a) Number of total clustered mutations per clone in our cohort. (b) Distribution of the log10-transformed genomic distance between point mutations that were identified as being clustered together (see “Methods” for the definition of a mutational cluster); note the distance between two unique mutations is only counted once. The number assigned to each treatment denotes the total number of cluster inter-mutational distances plotted, whilst the black horizontal line represents the median inter-mutation distance. P-values shown were computed using the ggpubr R package v0.4.0 (t test mean comparison of distances). (c) Distribution of point mutation cluster sizes, pooled by treatment for each cell line individually.
