Table 3 Multivariable analysis for the change in maximum CCA-IMT.

Variable	Univariable		Multivariable
Variable	Regression coefficient	P value	Regression coefficient	P value
Age, per 10 years	0.004	0.62	0.021	0.03
Men	0.009	0.69	0.013	0.56
Body mass index, kg/m²	0.004	0.11	0.004	0.06
Hypertension	− 0.033	0.21	− 0.040	0.13
Diabetes	0.016	0.34	0.020	0.25
Dyslipidemia	− 0.005	0.78	− 0.005	0.77
Current smoking	− 0.029	0.23	− 0.020	0.42
ASCVD	0.017	0.31	0.035	0.06
eGFR, per 10 ml/min/1.73 m²	0.005	0.38	0.010	0.15
Serum uric acid, mg/dl	− 0.009	0.27	0.009	0.15
Log-hs-CRP, ng/ml	− 0.001	0.88	− 0.006	0.37
Baseline mean CCA-IMT, mm	− 0.012	< 0.001	− 0.015	< 0.001
Allocation to febuxostat group	− 0.017	0.31	− 0.014	0.39

ASCVD atherosclerotic cardiovascular disease, CCA common carotid artery, eGFR estimated glomerular filtration rate, hs-CRP high-sensitivity C-reactive protein, IMT intima-media thickness.

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