Figure 5 | Scientific Reports

Figure 5

From: A novel computational method enables RNA editome profiling during human hematopoiesis from scRNA-seq data

Figure 5

RNA editing might influence lineage commitment and HSCs differentiation and self-renewal. (A) A summary of the number of lymphoid-specific and myeloid-specific editing sites and genes annotated by ANNOVAR. (B) The enrichment analysis of genes with lymphoid-specific editing sites involved in the differentiation of lymphoid cells. (C) The enrichment analysis of myeloid-specific edited genes involved in the differentiation of myeloid cells. (D) Venn plot showing the genes edited in lymphoid and myeloid cell lines. The editing sites of those genes are all located in 3ʹ UTR or exon coding region and involved in the differentiation of lymphoid cells, myeloid cells, respectively. (E) A summary of the number of HSC-specific editing sites and genes annotated by ANNOVAR. (F) The enrichment analysis of HSC-specific edited genes involved in hematopoietic stem cell differentiation. And genes involved in those pathways with editing sites are located in 3ʹ UTR or exon coding region.

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