Table 2 Echocardiography parameters recorded on wt and αMHC403/+ mice.

From: Cytoskeletal disarray increases arrhythmogenic vulnerability during sympathetic stimulation in a model of hypertrophic cardiomyopathy

ECHO parameters

wt

αMHC403/+

ctrl

ISO

Ate

Ate + ISO

ctrl

ISO

Ate

Ate + ISO

N

12

7

5

5

12

7

5

5

IVSd (mm)

0.77 ± 0.01

0.84 ± 0.01*

0.71 ± 0.03

0.80 ± 0.01

0.91 ± 0.02†

0.95 ± 0.02†

0.84 ± 0.01†

0.88 ± 0.02†

LVIDd (mm)

3.37 ± 0.06

3.16 ± 0.09

3.48 ± 0.13

2.93 ± 0.09*

2.95 ± 0.08†

2.55 ± 0.06a†

3.39 ± 0.16a

2.79 ± 0.14

LVPWd (mm)

0.80 ± 0.01

0.89 ± 0.03*

0.74 ± 0.03

0.84 ± 0.01

0.97 ± 0.03†

1.03 ± 0.03†

0.87 ± 0.01a†

0.91 ± 0.02#

IVSs (mm)

0.81 ± 0.01

0.89 ± 0.01*

0.75 ± 0.03

0.86 ± 0.01

0.98 ± 0.02†

1.06 ± 0.03†

0.89 ± 0.01a†

0.93 ± 0.02#

LVIDs (mm)

2.10 ± 0.04

1.34 ± 0.07*

2.37 ± 0.13

1.38 ± 0.10*

1.56 ± 0.09†

0.80 ± 0.07a†

2.12 ± 0.15a

1.29 ± 0.11#

LVPWs (mm)

0.83 ± 0.01

0.90 ± 0.01

0.78 ± 0.03

0.89 ± 0.01

1.02 ± 0.03†

1.13 ± 0.05a†

0.91 ± 0.01

0.96 ± 0.02#

EDV (ml)

0.099 ± 0.005

0.082 ± 0.007

0.109 ± 0.012

0.066 ± 0.006*

0.071 ± 0.006†

0.044 ± 0.003a†

0.101 ± 0.013a

0.058 ± 0.009

ESV (ml)

0.025 ± 0.001

0.007 ± 0.001*

0.036 ± 0.006*

0.008 ± 0.001*

0.012 ± 0.002†

0.002 ± 0.001a

0.026 ± 0.005a

0.006 ± 0.002

EF (%)

74.5 ± 0.9

91.7 ± 0.7*

67.3 ± 2.0*

88.5 ± 1.8*

83.6 ± 2.0†

96.5 ± 0.8a

74.7 ± 2.0a

89.4 ± 1.4

FS (%)

37.6 ± 0.5

57.6 ± 1.3*

32.1 ± 1.5

53.0 ± 3.0*

47.1 ± 2.1†

68.9 ± 2.0a†

37.8 ± 1.7a

53.9 ± 2.1#

SV (ml)

0.074 ± 0.003

0.075 ± 0.006

0.072 ± 0.006

0.059 ± 0.005*

0.058 ± 0.004†

0.043 ± 0.003a†

0.075 ± 0.008

0.052 ± 0.008

RWT

0.48 ± 0.01

0.57 ± 0.03

0.43 ± 0.02

0.58 ± 0.02

0.66 ± 0.03†

0.81 ± 0.04a†

0.52 ± 0.03a

0.66 ± 0.04#

  1. Echocardiography parameters recorded on wt and αMHC403/+ mice following in vivo treatment of 2 × 20 mg/kg isoproterenol in the absence or the presence of 1 mg/kg atenolol (Ate). IVSd—intraventricular septal wall thickness at end diastole, LVIDd—left ventricular internal diameter end diastole, LVPWd—left ventricular posterior wall end diastole, IVSs—intraventricular septal wall thickness at end systole, LVIDs—left ventricular internal diameter end systole, LVPWs—left ventricular posterior wall end systole, EDV—end-diastolic volume, ESV—end systolic volume, EF (%)—ejection fraction, FS (%)—fractional shortening, SV—stroke volume, RWT—relative wall thickness. Values are means ± SEM. Brown-Forsyth and Welch ANOVA was used to analyze differences between wt and αMHC403/+ mice followed by a Dunn’s test to correct for multiple comparisons. *p < 0.05 versus ctrl wt, ap < 0.05 versus ctrl αMHC403/+, †p < 0.05 wt versus αMHC403/+ under the same condition, #p < 0.05 versus ISO αMHC403/+.
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