Table 1 Effect of BrE treatment on histopathologic lesions severity in DOX-treated rats.

From: Boesenbergia rotunda displayed anti-inflammatory, antioxidant and anti-apoptotic efficacy in doxorubicin‐induced cardiotoxicity in rats

Groups

Disorganization

Focal necrosis

Degeneration

Inflammation

CON

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

BrE400

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

0.00 ± 0.00

DOX

3.00 ± 0.00**

1.80 ± 0.44**

2.20 ± 0.83**

1.40 ± 0.54**

BrE100 + DOX

1.60 ± 0.55++

0.90 ± 0.74++

1.20 ± 0.57++

0.75 ± 0.43++

BrE400 + DOX

0.70 ± 0.45++

0.20 ± 0.44++

0.80 ± 0.27++

0.30 ± 0.45++

  1. Cardiac injury severity was expressed as mean ± SD (n = 4). **Denotes significant differences compared to the CON and BrE 400 groups (p < 0.05); ++Denotes significant differences compared to the DOX group (p < 0.05). Grade 1 < 5% = mild. Grade 2 = 16–25% = moderate. Grade 3 > 35% = sever.
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