Figure 2 | Scientific Reports

Figure 2

From: Macrophage migration inhibitory factor (MIF) and its homolog D-dopachrome tautomerase (D-DT) are significant promotors of UVB- but not chemically induced non-melanoma skin cancer

Figure 2

Mif−/−, D-dt−/− and Mif−/−/D-dt−/− mice develop significantly later and fewer tumors during chronic UVB irradiation. Mice (n = 12 per group) were irradiated three times weekly for 25 weeks. (a) Representative photos of mice from each group. Photos were taken after euthanasia. (b) Kaplan–Meier plot showing the percentage of tumor-free mice. (c) Number of tumors per mouse in week 25. (d) Shown is the percentage of tumor area compared to the total dorsal area of each mouse. (e) Histologic classification of epithelial lesions. The incidence of SCC and papillomas in all KO groups was significantly different compared to WT mice (p < 0.001). (f) Representative H&E stainings of classified lesions in each group. While WT mice displayed less differentiated tumors, the KO mice displayed papillomas. Data represent mean ± SD. *p < 0.05; **p < 0.01. Scale bars = 50 µm.

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