Figure 7 | Scientific Reports

Figure 7

From: Evaluation and comparison of pharmacokinetic profiles and safety of two extended-release buprenorphine formulations in common marmosets (Callithrix jacchus)

Figure 7

Buprenorphine and norbuprenorphine metabolism in vitro by marmoset, macaque, and human liver microsomes. (A) Cytochrome P450 conversion of buprenorphine (Bup) into norbuprenorphine (NorBup) after 60-min incubation. (B) Glucuronidation of buprenorphine or norbuprenorphine into buprenorphine-3-glucuronide (Bup-Gluc) and norbuprenorphine-3-glucuronide (Norbup-Gluc), respectively, after 45-min incubation. Data is for a representative experiment.

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