Figure 5
From: In silico prediction of immune-escaping hot spots for future COVID-19 vaccine design
The immune-escaping hot spots on spike RBD. (A) The bubble plot of amino acid substitutions of contacting residues on RBD with IES. The colors represented the amino acid property, including blue for a positive charge, red for a negative charge, green for polar, gray for non-polar, and yellow for remains. The bubble sizes represented the strong to the weak immune-escaping ability of the IES. (B) The IES compared with neutralization titer data. The fold change is the geometric means of all subjects.
