Table 4 Subgroup analysis of pooled estimates of infarct size.

Species

0.02

 SD rats

9

 − 3.79

 − 5.09, − 2.50

75

 < 0.01

 Wistar rats

4

 − 6.60

-10.48, − 2.71

78

 < 0.01

 C57BL/6 mice

2

 − 2.19

 − 3.12, − 1.27

0

0.89

Type of I/R

0.24

 In vivo

10

 − 3.78

 − 5.46, − 2.10

77

 < 0.01

 Ex vivo

5

 − 4.94

 − 5.89, − 4.00

0

0.45

IS measure method

0.21

 AN/LV

6

−3.26

−4.29, −2.23

54

0.06

 AN/AAR

9

−4.61

−6.48, −2.74

84

 < 0.01

Drug delivery method

 < 0.01

 Perfused

6

 − 5.28

 − 6.42, − 4.14

61

0.03

 Intragastric

4

 − 2.06

 − 2.78, − 1.35

0

0.47

 Intravenous

5

 − 4.09

 − 6.29, − 1.88

78

 < 0.01

Duration

 < 0.01

 ≤ 30 min

8

 − 4.26

 − 5.66, − 2.86

74

 < 0.01

 30 min to 1 day

5

 − 7.59

 − 12.70, − 2.47

78

 < 0.01

 ≥ 1 day

4

 − 2.06

 − 2.78, − 1.35

0

0.47

Ischemia time

0.22

 ≤ 30 min

12

 − 4.40

 − 5.86, − 2.94

80

 < 0.01

 > 30 min

3

 − 3.11

 − 4.55, − 1.67

77

 < 0.01

Reperfusion time

0.02

 ≤ 2 h

8

 − 4.26

 − 6.15, − 3.08

81

 < 0.01

 > 2 h

10

 − 2.53

 − 3.24, − 1.82

50

0.09