Figure 4 | Scientific Reports

Figure 4

From: Generation of a familial hypercholesterolemia model in non-human primate

Figure 4

Administration of lipid-lowering drugs in LDLR KO monkeys. ((a) and (b)) Plasma total, LDL- and HDL-cholesterol concentrations in individual LDLR KO monkeys before (0 week) and 2 and 4 weeks after oral administration of atorvastatin (2 mg/kg/day; (a)) or rosuvastatin (1 mg/kg/day; (b)) once a day for 4 weeks. (c) Plasma total, LDL- and HDL-cholesterol concentrations in individual LDLR KO monkeys before (0 week) and 1 and 2 weeks after single subcutaneous injection of evolocumab (6 mg/kg). n = 3 in each experiment. Red bars indicate mean ± SD.

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