Figure 1

Chronic consumption of HSB diet does not alter operational short-term memory behavior, but induces alterations in reconsolidation and extinction of memory. (A) Schematic representation of method used in the Y maze test. (B) Evaluation of operational short-term memory by the Y maze test. The figure represents the calculation of arms alternation index (%) in the apparatus. (C) Representations of the novel object recognition and novel object localization test (ORT and OLT) protocol. (D,E) Measurement of total investigation time index (%) for ORT and OLT tests, respectively. (F) Schematic representation of protocol used in contextual conditioned fear. (G) Evaluation of memory evocation during the first 5 min of re-exposure to the context. (H) Representative curve of extinction during the entire re-exposure of the context memory evocation session. (I) Measurement of memory extinction, 24 h after the re-exposure session, during a 5 min duration session. Error bars represent the mean ± SEM; n = 9 (E,G–I), and 10 (B,D). Unpaired two tail T-student test (B,D,E,G,I), and Two-way ANOVA followed by Tukey’s post-test (H). *p < 0.05; **p < 0.01; ***p < 0.001.