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Figure 1

From: Cancer/testis antigen CAGE mediates osimertinib resistance in non-small cell lung cancer cells and predicts poor prognosis in patients with pulmonary adenocarcinoma

Figure 1

CAGE is increased after acquiring resistance to EGFR-TKIs resistance and is positively correlated with autophagy-related proteins. (a) Representative images of positive and negative expression of CAGE, pBeclin1Ser15, pAMPKɑT172, ATG5, and P62 in pulmonary adenocarcinomas (pADCs) (upper: positive expression, lower: negative expression; scale bar, 100 μm). (b) Correlations between CAGE and autophagy-related proteins in pADCs (Red, positive correlation; Blue, negative correlation). (c) Correlations between CAGE and autophagy-related proteins in EGFR mutated pADCs. Patients with pulmonary adenocarcinoma carrying EGFR mutations display exon 19 deletion and L858R in EGFR, but not T790M. (d) The H-scores of CAGE and ATG5 in paired tumor cells before and after acquisition of resistance to EGFR-TKIs. Paired biopsies were analyzed using the Wilcoxon Signed-Rank Test. *p < 0.05, Data were presented as the mean ± SEM).

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