Table 1 Sensitivity and specificity of M gene kit in comparison with other three commercial detection kits. Table (A) denotes the True positive, True negative, False positive and False negative* value of M gene kit against three commercial kits. Table (B), (C), (D) denotes performance evaluation of M gene kit compared commercial kit 1, commercial kit 2, commercial kit 3 respectively for COVID-19 detection.
From: M gene targeted qRT-PCR approach for SARS-CoV-2 virus detection
| Â | M gene kit* | |||||
|---|---|---|---|---|---|---|
(A) Commercial kit 1 | Negative | Positive | ||||
Negative | 46 | 4 | ||||
Positive | 2 | 68 | ||||
Commercial kit 2 | ||||||
Negative | 48 | 3 | ||||
Positive | 0 | 69 | ||||
Commercial kit 3 | ||||||
Negative | 47 | 1 | ||||
Positive | 1 | 71 | ||||
| Â | Sensitivity % (95% CI) | Specificity % (95% CI) | PPV % (95% CI) | NPV % (95% CI) | Accuracy % (95% CI) | Kappa % (95% CI) |
|---|---|---|---|---|---|---|
(B) Performance evaluation of M gene kit compared with commercial kit 1 for COVID-19 detection | ||||||
M gene kit vs commercial kit 1 | 97.14% (90.06–99.65%) | 92.00% (80.77–97.78%) | 94.44% (86.90–97.76%) | 95.83% (85.41–98.91%) | 95.00% (89.43–98.14%) | 89.66% (81.59–97.72%) |
(C) Performance evaluation of M gene kit compared with commercial kit 2 for COVID-19 detection | ||||||
M gene kit vs commercial kit 2 | 100% (94.79–100.00%) | 94.12% (83.76–98.77%) | 95.83% (88.47–98.57%) | 100% | 97.50% (92.87–99.48%) | 94.85% (89.09–100%) |
(D) Performance evaluation of M gene kit compared with commercial kit 3 for COVID-19 detection | ||||||
M gene kit vs commercial kit 3 | 98.61% (92.50–99.96%) | 97.92% (88.93–99.95%) | 98.61% (91.08–99.80%) | 97.92% (87.03–99.70%) | 98.33% (94.11–99.80%) | 96.53% (91.76–100%) |
