Figure 1 | Scientific Reports

Figure 1

From: Repurposing disulfiram, an alcohol-abuse drug, in neuroblastoma causes KAT2A downregulation and in vivo activity with a water/oil emulsion

Figure 1

Disulfiram has anticancer effects on neuroblastoma cell lines. (A) The viabilities of MYCN-amplified cells (SK-N-DZ, N91, SJ-N-TQ-24 and IMR-32) and non-amplified cells (SK-N-AS and SK-N-SH) were measured after 48 h of treatment with disulfiram (1 nM to 100 µM) or DMSO (n = 3). IC50 values are shown below the graph. (B) Cell cycle analysis of N91 cells treated with 25, 50 and 100 nM disulfiram for 48 h (n = 3). (C) Clonogenic assays in N91, SJ-N-TQ-24, SK-N-AS and SK-N-SH cells after 48 h disulfiram exposure at the indicated concentrations. After treatment, the drug was removed, and fresh cell culture medium (without drug) was added. Colony formation was measured after 2 weeks. Stars indicate significant differences between the treated group and the DMSO control (p ≤ 0.05 by unpaired Student’s t-test).

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