Table 2 Univariate and multivariate analyses of risk factors for local failure in patients with NPC.

From: Radiomics–clinical nomogram based on pretreatment 18F-FDG PET-CT radiomics features for individualized prediction of local failure in nasopharyngeal carcinoma

Characteristics

Univariate analysis

Multivariate analysis

Hazard ratio (95% CI)

P value

Hazard ratio (95% CI)

P value

Sex, n (%)

    

 Male

Reference

   

 Female

0.853 (0.453–1.605)

0.623

  

T stage

    

 1

Reference

   

 2

1.624 (0.578–4.563)

0.358

1.225 (0.433–3.463)

0.702

 3

2.103 (0.839–5.273)

0.113

1.040 (0.396–2.728)

0.937

 4

3.239 (1.264–8.297)

0.014

1.057 (0.379–2.948)

0.915

N stage

    

 0

Reference

   

 1

4.175 (0.989–17.631)

0.052

  

 2

2.392 (0.535–10.697)

0.254

  

 3

3.312 (0.734–14.947)

0.119

  

RS

    

 ≤ 0.27

Reference

   

 > 0.27

4.224 (2.328–7.667)

 < 0.001

3.171 (1.639–6.136)

 < 0.001

Age

    

 ≤ 44

Reference

   

 > 44

1.410 (0.785–2.532)

0.250

  

SUVmax

    

 ≤ 7.44

Reference

   

 > 7.44

3.625 (1.699–7.732)

 < 0.001

2.419 (1.073–5.455)

0.033

EBV-DNA

    

 ≤ 34,200

Reference

   

 > 34,200

1.709 (0.868–3.364)

0.121

  

SII

    

 ≤ 321.75

Reference

   

 > 321.75

1.351 (0.607–3.004)

0.461

  

NE

    

 ≤ 3.8

Reference

   

 > 3.8

1.519 (0.846–2.728)

0.161

  

Lym

    

 ≤ 1.5

Reference

   

 > 1.5

1.503 (0.676–3.344)

0.317

  

Hb

    

 ≤ 148

Reference

   

 > 148

1.462 (0.839–2.546)

0.180

  
  1. RS Rad-score, SII systemic immune-inflammation, NE neutrophil, Lym lymphocytes, Hb hemoglobin, EBV-DNA Plasma Epstein–Barr virus DNA, SUVmax maximum standardized uptake.
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