Figure 2 | Scientific Reports

Figure 2

From: Identification of endoplasmic reticulum stress-related signature characterizes the tumor microenvironment and predicts prognosis in lung adenocarcinoma

Figure 2

Unveiling endoplasmic reticulum stress-associated subtypes through consensus clustering and subsequent analyses. (A) Pie chart visualization of the results from a one-way cox analysis conducted on 256 ERSRGs, with a distinct subset of 56 genes emerging as significantly associated with patient survival. (B–D) In-depth consensus cluster analysis, applied to these 56 pivotal genes derived from a pool of 490 LUAD samples, with an optimal cluster number at k = 2, highlighting the formation of two distinct molecular subtypes. (E) Three-dimensional Principal Component Analysis (3D PCA) vividly delineating the segregation between Cluster 1 and Cluster 2, providing a spatial visualization of the distinct molecular landscapes. (F) Kaplan–Meier survival analysis curves showcasing the distinct overall survival (OS) trajectories for patients in both identified subgroups. (G) Heatmap showcasing the expression levels of the 56 ERSRGs across the two subtypes, emphasizing the molecular heterogeneity between the clusters. It was generated using the 'gplots' package (version 3.1.3) in R (version 4.2.1, [https://www.r-project.org/]). (H) Histogram representing the contrasting expression patterns of the 56 ERSRGs between the two subtypes. Created using the 'ggpubr' package (version 0.6.0) and 'ggplot2' package (version 3.4.2) in R.

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