Figure 2
Ferroptosis is involved in retinal I/R injury. Within 3 days of retinal I/R injury: (a) The contents of Fe2+, ROS, and MDA increased, and the content of GSH decreased (n = 3). (b) WB tests showed that the expression of TfR increased and the expression of FTH decreased (n = 6). (c) WB tests showed that the expression of SLC7A11 and GPX4 decreased (n = 6). (d) Real-time PCR showed that TfR mRNA expression levels increased and FTH, SLC7A11, and GPX4 mRNA expression levels decreased (n = 6). ns: not significant, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. control.
