Figure 4 | Scientific Reports

Figure 4

From: Deferoxamine attenuates visual impairment in retinal ischemia‒reperfusion via inhibiting ferroptosis

Figure 4

Deferoxamine inhibits ferroptosis. (a) Deferoxamine attenuated the increase in retinal iron, ROS, and MDA levels and the decrease in GSH levels (n = 3). (b) WB tests showed that deferoxamine inhibited the expression of TfR and increased the expression of FTH (n = 6). (c) WB tests showed that deferoxamine increased the expression of SLC7A11 and GPX4 (n = 6). (d) Real-time PCR showed that deferoxamine restored the levels of TfR, FTH, SLC7A11, and GPX4 mRNA (n = 6). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. I/R + saline.

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