Figure 5 | Scientific Reports

Figure 5

From: Deferoxamine attenuates visual impairment in retinal ischemia‒reperfusion via inhibiting ferroptosis

Figure 5

Deferoxamine attenuates retinal edema in the early stage after retinal I/R injury and inhibits RGC death and Müller cell proliferation. (a) Representative immunofluorescence images showed increased expression of GFAP (green) and decreased expression of RBPMS (green) in RGCs after I/R, and these effects were inhibited by DFO (n = 3). Blue: DAPI. Scale bar = 50 µm. (b) Typical diagrams of OCT after 48 h of retinal I/R injuries. (c) Quantitative analysis of the immunofluorescence intensity of GFAP and RBPMS (n = 3). (d) Deferoxamine significantly reduced retinal edema, which is likely to appear in the early stage after retinal I/R injury (n = 6). ***P < 0.001, ****P < 0.0001 vs. I/R + saline.

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