Figure 1
From: Transcriptional profiles of pulmonary artery endothelial cells in pulmonary hypertension
Differential gene expression in Group 1 pulmonary arterial hypertension vs. controls without pulmonary hypertension. (A) Volcano plot of fold-change in differential gene expression: Group 1 pulmonary arterial hypertension vs. controls.* (B) Heatmap of top differentially expressed genes. (C) Biologic pathways mapped from differentially downregulated genes. *p-values adjusted for multiple comparisons based on a false discovery rate (FDR) < 0.05. A pFDR < 0.05 was considered significant. PAH pulmonary arterial hypertension. CTD connective tissue disease. HIV human immunodeficiency virus. PoPH portopulmonary hypertension. CHD congenital heart disease. APAH associated pulmonary arterial hypertension.
