Figure 6 | Scientific Reports

Figure 6

From: Transcriptional profiles of pulmonary artery endothelial cells in pulmonary hypertension

Figure 6

Gene expression is similar across all subjects with pre-capillary pulmonary hypertension. (A) Heatmap and (B) principal component analysis (PCA) plot of differential gene expression between subjects with Group 1 pulmonary arterial hypertension (PAH) vs Group 2–5 precapillary pulmonary hypertension (PH), defined as mPAP > 20 mmHg, a PCWP ≤ 15 mmHg, and a PVR ≥ 3 Wood units. Despite within group heterogeneity, there appears to be similarities in gene expression between Group 1 PAH and precapillary Group 2–5 PH and there was no evidence of differential gene expression across precapillary PH from Group 1 versus Group 2–5. mPAP mean pulmonary artery pressure, PCWP pulmonary capillary wedge pressure, PVR pulmonary vascular resistance, CpcPH combined pre-post capillary pulmonary hypertension.

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