Figure 2

Univariate feature analysis in MataboAnalyst 5.0 (a) significance test in t test (Wilcoxon rank-sum tests) identified 661 significant metabolite features at (p ≤ 0.05); (b) fold change (FC threshold ≥ 2.0) analysis of metabolite features identified 481 significantly over- regulated and 548 down regulated metabolite features; (c) Volcano plot, up- and down regulated significant (p ≤ 0.05) metabolite features were clearly differentiated; (d) debiased sparse partial correlation (DSPC), partial correlations are established at p 0.0143, Q value 0.441 and partial coefficient 1.0 between those metabolites which usually go unidentified and remain unknown but represent bonafide entities for interpreting biological data.