Figure 3
Stratified meta-analysis for the overall dataset (all outcome parameters). The reported overall effect size was 18.9% (95% CI 14.5–23.2) indicated by the blue shaded area within the forest plot. Several aspects of the study design accounted for ‘between-study’-heterogeneity such as drug target/intervention, chosen SCI modality and corresponding neurobehavioral scale. (A) Interventions blocking the Nogo-receptor indicated the highest effect sizes within the overall dataset. (B) The most commonly used score for neurobehavioral assessment was the BBB-score in 67% of all included experiments. “Others” subsumes primate data revealing the largest effect sizes likely attributable to more subtle transection lesions with larger spared plasticity reservoirs. (ES: effect size, CI: confidence interval, BBB: Basso, Beattie, and Bresnahan score38, BMS: Basso Mouse Scale39).
