Table 4 Association analysis of the single SNPs instrument with Endometriosis with the histotypes of Ovarian Cancer.

From: Endometriosis and epithelial ovarian cancer: a two-sample Mendelian randomization analysis

SNPs

Endometrioid Carcinoma

Clear cell Carcinoma

Low malignant potential tumour

Associated Gene/cytoband

OR

95% CI

P-value

OR

95% CI

P-value

OR

95% CI

P-value

rs10167914

1.30

0.72–2.34

0.39

4.51

2.02–10.06

0.00

1.48

0.83–2.64

0.19

Interleukin (IL)-1A/2q13

rs10757272

1.92

0.73–5.01

0.18

2.83

0.74–10.85

0.13

0.65

0.25–1.68

0.38

CDKN2BAS/9p21.3

rs11674184

1.51

0.89–2.57

0.13

3.08

1.46–6.47

0.003

1.26

0.75–2.13

0.38

GREB1/2p25.1

rs12037376

1.47

0.87–2.46

0.15

2.20

1.09–4.46

0.02

1.89

1.11–3.14

0.01

WNT4/1p36.12

rs12700667

1.53

0.77–3.05

0.23

3.51

1.32–9.33

0.01

1.24

0.63–2.44

0.53

Inter-genic region upstream of plausible candidate genes NFE2L3 and HOXA 10./7p15.2

rs1448792

0.82

0.39–1.72

0.59

0.32

0.11–0.91

0.033

0.92

0.44–1.92

0.83

LINC01239 RNA/9p21.3

rs1537377

1.45

0.69–3.05

0.33

1.65

0.58–4.66

0.35

1.27

0.61–2.65

0.52

CDKN2B-AS1/9p21.3

rs17803970

1.02

0.51–2.06

0.96

5.08

1.78–14.50

0.002

0.97

0.49–1.94

0.93

SYNE1/6q25.1

rs1903068

1.52

0.85–2.70

0.16

4.09

1.81–9.27

0.001

1.58

0.90–2.79

0.11

KDR/4q12

rs1971256

3.26

1.60–6.63

0.001

3.01

1.11–8.15

0.03

0.76

0.37–1.57

0.46

CCDC170/6q25.1

rs2206949

1.95

1.01–3.75

0.05

2.64

1.06–6.55

0.04

1.69

0.89–3.22

0.11

ESR1/6q25.1

rs6546324

1.18

0.53–2.60

0.68

0.72

0.24–2.21

0.57

1.35

0.62–2.94

0.45

ETAA1/2p14

rs71575922

0.88

0.42–1.86

0.75

6.01

2.21–16.33

0.00

1.14

0.56–2.39

0.71

SYNE1/6q25.1

rs74485684

2.93

1.38–6.23

0.005

1.76

0.61–5.02

0.29

1.30

0.62–2.69

0.49

FSHB/11p14.1

IVW

1.50

1.24–1.81

3.18E−05

2.56

1.75–3.73

1.09E−06

1.28

1.08–1.53

0.005

 

MR-Egger

1.28

0.52–3.15

0.60

7.69

1.41–41.78

0.05

2.37

1.06–5.30

0.06

 
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