Table 4 Pharmacogenomics guidelines for personalized aspirin delivery32.

From: Establishment of a forward primers-superposed amplification analysis for accurate aspirin pharmacogenomic measurement

Genetic polymorphism

Phenotype scoring

Scoring grade and individualized advice

PEAR1

rs12041331, G > A

GG: 2 points

GA: 1 point

AA: 0 point

Aspirin resistance

0 point: low response, recommended drug change or single-use dose 200 mg or more based on platelet function test

1 point: intermediate response, recommended single-use dose 150 mg

2–4 points: high response, recommended single-use dose 75–100 mg

GP1BA

rs6065, C > T

CC: 0 points

CT: 1 point

TT: 2 points

LTC4S

rs730012, A > C

AA: 0 points

AC: 1 point

CC: 2 points

Adverse reaction

0 point: low risk, medication safe, no prompts

1 point: certain risk, this suggests some risk of an allergic reaction and the patient is instructed to be closely observed

2 points: high risk, it is recommended to pay close attention to the risk of adverse reactions or switch to other drugs if they occur

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