Figure 1
From: CPT1A as a potential therapeutic target for lipopolysaccharide-induced acute lung injury in mice
CPT1A overexpression alleviated lung injury and suppressed the inflammatory response in the lungs of ALI mice induced by LPS. (A) The survival rate of mice subjected to LPS. (B) The lung histopathological change by H&E staining. Scale bar: 100 μm. (C) Lung inflammation score. (D) The lung wet-to-dry ratio was determined. (E, F) BALF was collected to measure the number of cells or the amount of protein. (G, H) Il-1β and Tnf-α mRNA in lung tissue were determined. (I, J) Levels of cytokines (IL-1β and TNF-α) secretion in BALF were determined. n = 5, **P < 0.01 and ***P < 0.001.
