Figure 1
From: microRNA blood signature for localized radiation injury
Experimental design. Two independent mice cohort were used with the same experimental design, to perform a broad-spectrum profiling of miRNAs (cohort 1) and then a targeted study (cohort 2). For each cohort, mice were irradiated according to 4 irradiation groups with 20, 40 or 80 Gy and 0 for the control group (N = 15/groups) with 10 MV X-rays with a LINAC at a dose rate of 2.5 Gy/min under anesthesia performed with isoflurane (D0). Injury score and blood perfusion analysis were performed at D7, D10 and D14. Mice were euthanized at D14 after blood samplings.
