Figure 4
From: microRNA blood signature for localized radiation injury
Broad-spectrum analysis. (A) Multi-block sPLS-DA scatter plots, with miRNA block = plasmatic expression of 18 miRNA among 750 miRNA analyzed; clinical block = injury score and cutaneous blood perfusion data at days 7, 10 and 14; blood block = results of CBC and plasmatic CRP level at D14. (B) Significant correlation between the first miRNA component of the DIABLO model with the injury severity at Day 14 after sPLS-DA, allowing to distinguish mice according to their injury severity and their group of dose (p-value = 0.0048, R2 = 0.19). (C) List of the 18 miRNAs selected (D) Circle plot providing a visualization of the multi-scale positive (orange) or negative (black) correlations between covariates of each block (estimated correlation greater than 0.5). These covariates are linked by a line inside the circle (colored according to the correlation sign). The lines outside the circle show the overall expression of the covariates across the dose groups. Control group N = 9, 20 Gy N = 11, 40 Gy N = 5, 80 Gy N = 11.
